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On January 12, 2009, CMS issued final regulation CMS-4131-FC, “Medicare Program; Medicare Advantage and Prescription Drug Benefit Programs: Negotiated Pricing and Remaining Revisions”. This regulation finalizes a number of provisions from the May 16, 2008 proposed regulation impacting the Medicare Advantage, Prescription Drug and the Retiree Drug Subsidy programs. Regulations to implement related provisions from the Medicare Improvements for Patients and Providers Act (MIPPA) are also included.